![]() Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.Īll of our content is written by scientists and people with a strong science background. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. We believe that the most accurate information is found directly in the scientific source. We examined the relationships between NLR, PLR, PNI, and overall survival and cancer survival using Cox-proportional hazard models.SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Subgroup analyses were done to examine the relation between hs-CRP categories and all-cause mortality and cancer mortality according to smoking status (current, former, and nonsmoker) and obesity status (BMI ≥25 kg/m 2, and <25 kg/m 2). We also conducted the same analysis on subjects excluding those who died within 2 years after medical check-ups. We used Cox-proportional hazard models after adjusting for potential confounders, such as age, sex, BMI, smoking status, hypertension, diabetes, total cholesterol level, high density lipoprotein (HDL)-cholesterol level, regular drinking (or not), regular exercise (or not), and monthly income. The HRs for all-cause and cancer mortality (including site-specific cancers) were estimated according to the 3 hs-CRP categories. The Kaplan–Meier method was used to describe the relationship between log-transformed hs-CRP and mortality from all causes and from cancer. Here, we sought to investigate the association between serum hs-CRP levels and mortality from all-causes, overall cancer, and site-specific cancer and we further examined the relationship of survival and cancer survival with inflammation-based prognostic scores including neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and prognostic nutrition index (PNI). However, no study has yet examined the possible association of hs-CRP levels and cancer death or site-specific cancer death in an Asian population. Recently, Lee and colleagues showed an association between hs-CRP concentrations and all-cancer risk and site-specific-cancer risks in 80,781 healthy Koreans ( 15). Some evidence suggest that there is a relationship between hs-CRP and cancer in Asian populations. For example, the 4 main causes of cancer mortality in the United States in 2007 were lung, breast, colorectal, and prostate cancer ( 13), whereas those in Korea in 2009 were lung, liver, stomach, and colon cancer ( 14). The common causes of cancer mortality among Koreans, however, appear to differ from those of people in other countries. Most of the studies on the influence of hs-CRP on cancer mortality have originated from western countries ( 7–12). Cancer Epidemiol Biomarkers Prev 21(11) 2076–86. Impact: As a marker for chronic inflammation, hs-CRP assists in the identification of subjects with an increased risk of cancer death. Elevated hs-CRP was also associated with an increased risk of site-specific mortality from lung cancer for sexes combined (2.53 ).Ĭonclusions: This study suggests that elevated levels of hs-CRP in apparently cancer-free individuals may be associated with increased mortality from all-causes and cancer, in particular, lung cancer in men, but not in women. The adjusted HRs (aHR 95% confidence interval ) of subjects with hs-CRP ≥3 mg/L for all-cause and cancer-related mortality were 1.38 (1.15–1.66) and 1.61 (1.25–2.07) in men, and 1.29 (0.94–1.77) and 1.24 (0.75–2.06) in women, respectively, compared with subjects with hs-CRP ≤1 mg/L. Results: During an average follow-up of 9.4 years, 1,054 deaths, including 506 cancer deaths, were recorded. Baseline serum hs-CRP levels were obtained and subjects were followed up for mortality from baseline examination until December 31, 2008. Methods: A total of 33,567 participants who underwent routine check-ups at a single tertiary hospital health-screening center between May 1995 and December 2006, and whose serum hs-CRP level data were available, were included in the study. We investigated the association between serum hs-CRP levels and all-cause mortality, cancer mortality, and site-specific cancer mortality in apparently cancer-free Koreans. Background: High-sensitivity C-reactive protein (hs-CRP) is an important inflammatory marker, and inflammation is known to be involved in the initiation and progression of cancer.
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